A retractable barb needle for drug darts

A Statistician Plays Darts

Darts is enjoyed both as a pub game and as a professional competitive activity. Yet most players aim for the highest scoring region of the board, regardless of their skill level. By modeling a dart throw as a 2-dimensional Gaussian random variable, we show that this is not always the optimal strategy. We develop a method, using the EM algorithm, for a player to obtain a personalized heatmap, wh...

Target identification using drug affinity responsive target stability (DARTS).

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have developed a method, drug affinity responsive target stability (DARTS), which takes advantage of a reduction in the protease susceptibility of the target protein upon drug binding. DARTS is universally applicable because it requires no modific...

Retractable Contracts

In calculi for modelling communication protocols, internal and external choices play dual roles. Two external choices can be viewed naturally as dual too, as they represent an agreement between the communicating parties. If the interaction fails, the past agreements are good candidates as points where to roll back, in order to take a different agreement. We propose a variant of contracts with s...

A novel design for a small retractable cylindrical mirror analyzer

Retractable roof structures

j This paper presents a new concept for retractable roof structures. The new structures consist of a foldable lattice of beams connected by cylindrical joints, to which covering panels or membranes are attached. These structures fold towards their perimeter and there is practically no limit to their shape. Solutions to the key problems that have to be solved in the course of the kinematic desig...